Mesothelioma (MESOTHELIOME) and Alomint (AMIANTE)

 

Introduction:
 
 Dear offer you today to look strong for mesothelioma Alomnit and grandmother when a friend of mine and summarized in a book you initially Mesothelioma is a malignant tumor of the tumors resistant to all types of processors are known to this day. Have been established Alomint exposure to fibers in the period of a person's life around this tumor (80%) cases and studies showed that the tumors appear after the medium-long period of exposure to fibers Alomint, estimated at 20 to 40 years.
     The number of cases of this tumor is increasing continuously and regularly in the industrialized countries, statistics indicate that this number will double in the next twenty years.
 
Alttoralsrere:
     Tumors are often middle-men (85% of the injuries) 'enactment of the sixties. Injury pleurisy dominated largely on the rest of the depositions, as studies show that the injuries you see in the pleural 92% of cases compared to 8% of the injuries blank (PERITOINE) but in very rare cases the tumor may affect the Pericardial heart or testicular sheath.
 
     Can prove exposure to Omint in about 80% of the injuries in men and only 50% of the injuries in women.
     Reported cases of infection is very rare tumor in children and adolescents.
 
Clinical symptoms of mesothelioma (Mizotellma)
 Show clinical signs of mesothelioma are usually late and vague, often have chest pain but may spread into the shoulder Ooabatn, accompanied by distress and symptoms of self-recurrent effusion pleurisy and one-sided. Get the right side is larger than the left side injury (60% of injuries in the pleura right).
 In some cases, Unusually 'especially when older persons' can pretend to mesothelioma symptoms Wind vest or to discharge the blood.
Common symptoms are associated with non-specific and multi-thermal rise above such 'sweating' fingers Aloboukratip and hemolytic anemia as well as it can be noted the high number of Aalsfihat and high blood calcium.
 
 
Photogrammetry Alti_khis:
 
_1_ Image Alsdralcaaip regular:
  Can show the presence of effusion Janabi, 'usually on one side' is associated in cases of advanced Btzmk in pleurisy with a Noatye Halimipaly pleural surface of the membrane 'These signs often associated with lack of functional size of half the injured chest.
Spread of the tumor Mediterranean to the chest wall is accompanied by signs of bone necrosis and corrosion on the level of the ribs and paragraphs.
In about (30 to 50%) of the cases can be observed in calcified plates sidearms.
 
_2_ CT scan or Palmfras (SCANNER):
Tags show the same but the former is more sensitive than radiography school is therefore possible to detect small lesions and to measure its dimensions and the dissemination of accurate, which Isa'daly take appropriate remedial plan also helps to assess the effectiveness of treatment.
Can by CT scan detection of pleural Altzmkat Aalhasrp around the whole surface of the lung and in cases of advanced mesothelioma, also can detect Alnoati papillary tumor on the surface of the tumor side and extensions to the grooves between the pulmonary lobule.
 
 
 _3_ Magnetic resonance imaging (IMAGERIE PAR RESONANCE MAGNETIQUE):
Began its use in the diagnosis of these tumors for many years, medical teams, which use it only refers to the results better than those of CT scan in the study of medium-sized tumors, but the truth is that the priority of one over the other linked to experience the same medical staff to use this or that.
 
     The diagnostic pathological:
 _1_ Lumbar pleurisy:
Is usually the first screening of the disease being 'liquid is usually bleeding and rich in protein and DNA Alheialorini' value Alamadgi cancer antigen (ANTIGENE CARCINOEMRYONNAIRE, ACE) for Atertf 'not in the pleural fluid and blood serum.
Cytological methods of pleurisy may be directed to the diagnosis but remains a very difficult diagnosis cellular preferably vouch for its authenticity Boukzaap tissue. Usually tumor cells of the tumor and the Mediterranean in the pleural fluid are combined to form the body of Totti 'cells featuring the vesicles in the vicinity of Hullagha phones and ownership of the central core containing the nucleus slash redness.
 
 _2_ Biopsy needle (needle ABRAMS):
Could lead to a definitive diagnosis in about (20 to 70%) of cases, depending on the size and quality according to the tumor but remain a small sample size is not sufficient for an analysis of patients with good or anatomical study of immunological complete.
 
_3_ Biopsy obtained by Ptnzir pleurisy:
One of the best samples for the diagnosis of these tumors to secure sufficient volumetric parts of the tumor tissue, which facilitates the examination and allow for all types of textile Altleuenat immune achieved in today's tremendous progress in the precise diagnosis.
Indeed, the difficulty of diagnosis are mainly produced from these tumors take many forms of biological tissue may resemble a lot of other tumors that affect pleurisy 'idiosyncratically Differential be very difficult in most cases and that when it comes to the distinction between CARCINOME Carcinoma, mesothelioma (MESOTHELIOME). In these cases highlight the importance of using methods of marking immune system.
 
Methods of marking the immune positive mesothelioma can be classified according to their importance (for now) as follows:
 
 1_ marking immune b (CALRETININE) to an informant (ZYMED): positive coloration is located in the cytoplasm and cell nucleus.
 2_ marking immune b (CYTOKERATINE 5,6).
 3_ marking immune b (HMB1) to an informant (DAKO): positive labeling must be limited to the cell membrane of tumor cells.
 
 Turn 'in Carcinoma (carcinoma)' and one or more of the following methods of marking immune be positive:
 
 TTF1 is usually positive in tumors arising at the expense of lung tissue and gland and in turn be negative in
 100% of mesothelioma cases.
ACE 'Ber.Ep4' CD15 'MOC 31' B72.3
 
There are less common (representing about 15% of medium tumors (with similar tissue-malignant tumors of connective tissue (Ahlgren (SARCOMA In these cases it is necessary to resort to labeling immune system and in particular antibodies using the CYTOKERATINES) of the form (KL1) or (AE1, AE3) where these Altleuenat positive 100% in the Mediterranean while the tumors are generally negative in the tumors Algarnip.
 
 _4_ Diagnosis peeling the pleura:
     Resort to peeling pleurisy in the case of adhesions sidearms do not allow for theory-Janabi.
 
 _5_ Diagnostic samples obtained by the wide during surgery (removal of pleurisy and pneumonia): often this type of surgical interventions is therapeutic and allows to study the spread of tumor (a lung Bulgmip the chest wall).
 
 _6_ The importance of electron microscope:
He has lost its importance in the diagnosis of current medium-sized tumors in Mndhu Diagnosis marking the emergence of new immune system.
Can be seen in an electron microscope study of tumors when the medium is the number of signs of quality for these tumors
 
               Â The existence Zgabat long and winding all around the cell
               B-particles and the presence of a hyphen between the tumor cells (DESMOSOME)
               C _ a dense fibrous tumor on the cell nucleus.
 
The causes of mesothelioma (ETIOLOGIE):
 
Since the article (WAGNER. al) in 1960 in South America, which referred to the diseases of miners Alomint and in people living near these mines has begun to global attention and numerous studies have linked exposure to the fibers and the incidence of tumors Alomint pleurisy
 
What is Alomint:
Is a natural mineral fiber used for cryptographic excellence in thermal insulation. More countries producing and exporting Omint are Canada and Australia.
Mndhu beginning of the century used three types of fibers Alomint:
 
 1_ Alomint White (CHRYSOTILE) from the family of (SERPENTINES) and represented 'in 1980 hit (95 to 98%) of the World Trade Omint
 2_ Alomint Blue (CROCIDOLITE) from the family of (AMPHIBOLES)
 3_ Alomint brown (AMOSITE) from the family of (AMPHIBOLES).
 
 Some cases of mesothelioma reported after non-occupational exposure to fibers Alomientip of the type known as (TREMOLITE) or ((ZEOLITE from the family of (AMPHIBOLES) existing freely in the environment for some Turkish villages in the area (CAPPADOCE) have been recorded in these villages, the highest global tumors of infection medium.
Professions that use the Alomint are mainly shipbuilding trades 'workshops plumbing, electrical wiring' in the thermal insulation specialist workshops and car repair workshops.
We must not forget that some of the buildings that were built in the sixties and seventies had painted from the inside Balomint means of thermal insulation and is currently a source of danger to the people who live long in this Almnchaouat.
Several years ago 'and gradually' in the advanced industrial countries appeared Alomint laws that prohibit the use of thermal insulation in building ships and buildings and encourage the use of other insulating materials but in third world countries do not have such laws, such as exposure to these tumors is not known professional results.
 
Other reasons for non-tumor medium Alomint:
Not so far proved the role of fiber and fiber glass or rock mineral wool insulation role in the development of these tumors, possibly a result of lack of sufficient time to assess the injuries and is currently believed that there are some characteristics that may play a role Imradia catalyst for the emergence of these tumors, and these properties may be mentioned installation chemical fibers' length and Qatar fiber and finally their ability to decay in the community dynamic.
 
There are some studies that have raised the subject of the role of exposure to radiation in the tumor Mediterranean, especially that some cases reported after radiotherapy for breast tumors 'for Hodgkin's disease Almnsfi' Alsiminom and Alinvroblastom.
 
 The role of the sludge leaching:
In some cases of mesothelioma have been to prove the existence of the sections (ADN) of meat in the name of leaky Aerovp (SV40), as well as the presence of antibodies Ddip of the form (ANTI.TAG) in the serum of infected, but there is disagreement among specialists about the medium tumors fact that these effects febrile leaky On the role of sludge percolating in the emergence of these tumors. Some believe that the presence of objects in the febrile leaky tumor cells is linked with the extensive use of polio vaccine in some areas between 1955 and 1963. Finally, can detect these pieces febrile percolating in other tumors such as lung tumors and brain ...
 
Domestic Preparedness:
 Some cases of mesothelioma in the same family but there is as yet no proof of the existence of a gene clearly believed that these cases belong to the persons had been subjected to the same of the organism to the emergence of the tumor.
 
 
 WHO classification of tumors pleurisy 1999:
 
_ Tumors intact:
_ Tumor semi Algdomani (TUMEUR ADENOMATOIDE)
_ Malignant tumors:
_ Tumor medium Alzaarani (MESOTHELIOME EPITHELOIDE)
_ Medium mixed tumor or biphase (MESOTHELIOME MIXTE ou BIPHASIQUE)
_ Tumor medium Garnaoui (MESOTHELIOME SARCOMATOIDE)
 _ Tumor medium structural Rabat (MESOTHELIOME DESOMOPLASTIQUE)
_ Medium tumors with other characterizations such as discrimination discs' rhabdomyoma and nervous
_ Hyperplasia is typical of the cells to medium (HYPERPLASIE ATYPIQUE)
_ Similar tumors such as mesothelioma Endocrine Carcinoma (ADENOCARCINOMA) and tumor vascular endothelial bloody Alzaarani
     (HEMANGIOENDOTHELIOME EPITHELOIDE)
_ Anakail (METASTASES).
 
 However, this classification did not satisfy him all taxonomists world are working at the present time the formation of a new label soon.
 
Clinical classification of tumors according to the prevalence of medium-tumor (BUTCHA and amended by
BOUTIN)
 
_ The tumor affects only pleurisy and parietal pleural membrane of the diaphragm and the region of one: Phase IA
_ The tumor affects visceral pleurisy: Phase IB
_ The tumor affects the chest wall or fair, in the same body: Phase IIA
_ Tumor affects pleurisy on the other side: Phase IIB
_ Transfer of tumor outside the chest and held Albulgmip click or collarbone illusions PERITOINE: Phase III
_ Transfers far: Phase IV.
 
Taxonomy of the group of experts interested in the global medium-sized tumors
     (IMIG: INTERNATIONAL MESOTHELIOMA INTEREST GROUP)
 
Injury and pleurisy parietal pleural membrane of the diaphragm muscle (T1a)
Visceral injury pleurisy (T1b)
Injury pleurisy Almnsfi 'diaphragm muscle or the lung tissue (T2)
The development of localized tumor, but in principle is subject to the eradication of surgery (T3)
The development of localized tumor, but a non-surgical eradication: hit the chest wall and through the diaphragm illusions of 'pleurisy in the
Side 'members of the fair' heart 'of the spine (T4).
 
There is no injury to a Albulgmip (N0)
Injury Albulgmip decade in the center of the same lung (N1)
Injury in the contract Albulgmip unfair or nodal group in the same mammalian inner side (N2)
Infection Albulgmip decade in the center of the lung on the opposite side and the injury of the contract above the clavicle (N3).
 
          T1a N0 M0 stage (Ia)
          T1b N0 M0 stage (Ib)
          T2 N0 M0 stage (II)
Each T3 M0 or all of the N1 M0 or all of the N2 M0: stage (III)
All T4, every N3, all M1: Stage (IV).
 
Treatment:
There is still no effective treatment for tumors medium For this reason, we are witnessing the plurality of treatment methods.
 
_ Chemotherapy on public streets:
Chemical processing and a single drug results were very bad (in response at zero to 14% of cases), which called for
To resort to multiple drug treatment 'Separate results relatively, but not satisfactory.
 
_ Topical chemotherapy within the cavity pleurisy:
This method allows using a high concentration of drugs, but unfortunately does not reach the chemical property of the depth of the tumor, which makes
 Effectiveness is very limited. Drug user is usually the Cisplatine.
 
_ Radiotherapy:
Treatment is limited by the presence of members of the vitality of irradiation does not bear the high quantities (such as the heart 'spinal cord' lung 'Marri
And liver), but radiotherapy may be used in conjunction with other treatments, particularly surgery, is now Msttabp
Complementary therapy after surgery or after endoscopy pleurisy to avoid the spread of cells Alormipily the chest wall and finally used as therapy
Analgesics pain in the areas of deployment of the tumor.
 
_ Surgical treatment:
Have no place but in the early cases of the tumor is based on removal of a lung and pleurisy wide (lung 'side' Pericardium 'half
Diaphragm muscle and the contract Albulgmip). In most cases, 'This surgery does not allow the removal of the tumor completely and that
In addition to radiotherapy or chemical weapons.
 
_ Immunotherapy within pleurisy:
Used in cases of early (stage I, II) and is based on injections (interferon gamma) within the cavity pleurisy '
The response was limited (approximately 20%) with a better response in phase I were to get a satisfactory answer as long as
For a period of 17 to 19 weeks.
Believed that the way the impact of the (interferon gamma) back to the effectiveness of toxicity or tumor cells by modified
The answer's immune cells to the deadly cancer cells.
 
 
In conclusion:
 Mesothelioma tumors that arise in people who have been exposed or fiber Alomint therefore prevention of these tumors based on the detection spots Alomint 'knowledge of people exposed to' take steps to prevent exposure Allazmp fiber Alomint and in particular
Stop the use of this material in industry and construction because the danger is not limited to construction workers as there is a real danger to people living in these buildings Ooaji and Almnchaouat.
 The physician's role is to refer to the dangers of Alomint and take the necessary steps for early diagnosis and treatment of early tumors medium 'here highlights the role of slasher patients who must gain sufficient experience in the diagnosis of these tumors and the use of immune Altleuenat if necessary, and greetings to all and wish you safety.
 
      
 

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